Double-blind Trial of Propranolol (inderal) in Angina of Effort.

نویسندگان

  • S C SRIVASTAVA
  • H A DEWAR
  • D J NEWELL
چکیده

Blockade of adrenergic beta-receptors has a possible application in the management of angina of effort, presumably through reduction of exercise-induced tachycardia and thereby of total cardiac work. A clinical trial with pronethalol has shown encouraging results (Alleyne et al., 1963). Its further use has, however, been limited partly by frequent central-nervous-system side-effects and partly by its carcinogenic action on mice (Paget, 1963). Propranolol (I.C.I. 45520, Inderal), a newly developed agent with a similar mode of action, has been shown to have a therapeutic effect about 10 times greater than that of pronethalol but without demonstrable carcinogenic potential (Black et al., 1964). The results of its use in a double-blind trial in) cases of angina of effort are reported.

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عنوان ژورنال:
  • British medical journal

دوره 2 5411  شماره 

صفحات  -

تاریخ انتشار 1964